GlucoScript Detail Page
Allergen Statement: Each ingredient in this product is non-GMO. This product is FREE of the following common allergens: milk/casein, eggs, shellsh, tree nuts, peanuts, wheat/gluten, and soybeans.
Contains no artificial colors, flavors, or preservatives. This product does NOT contain magnesium stearate.
Berberine is a compound that scientists extract from the Oregon Grape plant. Medicinal uses of berberine have been documented in China since 3000 BC. Berberine has been shown in studies to lower blood glucose (sugar) as effectively as metformin, a popular prescription medicine for diabetes. A study in the Journal of Clinical Endocrinology and Metabolism in 2008 found that berberine caused a significant reduction in hemoglobin A1c (HbA1c) and improved cholesterol ratios.
Cholesterol concerns? Berberine upregulates LDL receptor expression, allowing for more effective clearance of LDL from the bloodstream. It does NOT act like a statin, thus it does not affect the complex biosynthesis pathway, nor interfere with CoQ10 production.
In diabetics using insulin, the addition of berberine allowed for increases in both fasting and post-prandial C-peptide, suggesting that long-term berberine intake might improve insulin secretion. Additionally, berberine has been shown to increase insulin receptor expression, indicating that it supports glycemic control by promoting endogenous production of insulin while improving utilization of insulin.
Berberine has antimicrobial and antiviral activity, and inhibits growth of HSV (herpes simplex virus). By inhibiting intestinal disaccharidases involved in digesting carbs, berberine may reduce post-prandial blood glucose. Two-hour area under the curve (AUC) for blood glucose levels after sucrose and maltose loading were lower in berberine-treated animals than in untreated controls. Similar findings for berberine’s influence on carbohydrate-digesting enzymes are supported by observations in cultured human cell lines. Finally, berberine been shown to reduce pro-inflammatory cytokines produced in the body.
Resveratrol is a powerful antioxidant found naturally in red grapes, berries and cacao. It has hundreds of scientific papers on it. The medical literature shows that resveratrol improves insulin sensitivity. It improves thyroid function, which in term supports blood sugar regulation. It protects eyes from harm which may lead to blindness, a common complication of high blood glucose. Resveratrol is also thought to help a person attain healthy cholesterol ratios. In the case of autoimmune disorders, well-designed clinical trials have shown that resveratrol can help relieve pain, fatigue and inflammation as well as prevent neuronal cell death. Some scientists go so far as to suggest resveratrol for serious memory disorders. This is a powerful free-radical scavenger, protecting DNA which helps reduce risk for cancer.
Holy Basil Leaf (Ocimum sanctum)
Holy Basil is also known as “Tulsi” and is famous for its adaptogenic effect on adrenal glands and the ability to impact cortisol rhythm. A reduction of cortisol leads to a higher sense of well-being and relaxation. Holy Basil has anti-inflammatory properties. It has a stabilizing effect on blood sugar and cholesterol ratios. Animal models have shown benefits to post-prandial blood glucose levels and fasting blood glucose.
Because of its remarkable effect on cortisol secretion, glucose regulation and lipids, Holy Basil is included in GlucoScript. It is protective to the liver as well. As an aside, this herb has demonstrated antifungal, antibacterial and antiviral properties.
Bilberry (Vaccinium myrtillus)
This is also known as a huckleberry, or European blueberry. The natural blue pigment is a strong antioxidant that quells free radicals. Bilberry is best known to impact eyesight. Blindness is a complication of diabetes. Vision is important, as is blood glucose. Using animal models, researchers have shown that bilberry extract lowered blood glucose and increased insulin sensitivity by activating AMP-activated protein kinase (AMPK) in white adipose (fat) tissue, skeletal muscle and the liver. AMPK stimulates fat breakdown in liver and muscle (a good thing) and modulates insulin secretion by your pancreas.
Studies support a protective influence of vitamin D on Type 2 diabetes mellitus risk. Many people are insufficient in vitamin D. Approximately 77% of the US population. Most cross-sectional and prospective studies in various populations show an inverse association between circulating 25-hydroxyvitamin D (vitamin D) and fasting plasma glucose, impaired glucose tolerance, hemoglobin A1c, metabolic syndrome, and incidence of prediabetes. Taken together, the data suggests the vitamin D is helpful to people struggling with these types of issues.
This mineral improves glucose uptake into the cell. It inhibits cross-linking of glycated collagen, implicated in diabetes and myocardial stiffening. Chromium is touted to help balance blood sugar and control cravings. In one well-designed clinical trial, people with Type 2 diabetes who took chromium supplements had better hemoglobin A1c values, fasting blood glucose levels and blood sugar control (compared to placebo). Body builders like chromium because it may improve lean muscle, and reduce body fat.
Niacin (Vitamin B3) and 5-MTHF (Folate)
B vitamins are important for your heart, and cardiac complications are rather common in patients with diabetes and metabolic syndrome. These 2 nutrients help you to reduce homocysteine, which -when elevated- can increase your risk for heart attack and neurotoxicity. Both the niacin and folate are in body-ready, highly bioavailable forms and they are also needed for your body’s natural detoxification pathway, the methylation pathway. The methylation pathway will help you to produce important compounds in the body such as SAMe and glutathione, two major players in detoxification and general health and well-being. You can read more about methylation here. The “Metafolin” is a high-quality methylated form of folate. This is NOT folic acid, this is genuine folate. A study in Vascular Medicine has concluded that this B vitamin “can improve endothelial dysfunction in type 2 diabetics independent of homocysteine-lowering…”
As an aside, niacin and folate are sometimes used to improve blood circulation which can be a problem in people with cold hands and feet, and people with restless arms or legs.
Zinc is an antioxidant mineral that supports immune function. Infections, especially skin infections are common in people with elevated blood glucose. Zinc deficiency may play a role in people with abnormal immune function in Type 2 diabetes according to research. In fact, people with diabetes are known to have insufficient amounts of zinc in their blood, and higher amounts in their urine. Previous research has suggested that appropriate levels of zinc in the blood are linked to slower risk of diabetes. Zinc is also known to protect the skin, and wound healing is very important in people with abnormal blood sugar.
Accumulating evidence suggests that reactive oxygen species (ROS) known more commonly as “oxidative stress” is part of the cytokine cascade that leads to dangerous complications in diabetes. Antioxidant agents, particularly, fat-soluble ones like natural vitamin E are thought to ameliorate some of the free radical damage. Gamma tocopherol, an isomer of vitamin E that is found naturally in small amounts in food has been studied and shown to benefit people with type 2 diabetes. It is a gentle platelet inhibitor so it may be of value for people concerned about thrombosis. According to a scientific article published in The European Journal of Nutrition, gamma tocopherol “may reverse or delay the onset of insulin resistance and resultant pathogenesis.”
Magnesium and Potassium
A very small amount of these two minerals are included for beta cell function. Beta cells help product insulin and are dependent on various minerals to secrete insulin. Magnesium and potassium are often depleted in individuals who enjoy coffee or tea. Magnesium and potassium are also used for healthy blood pressure regulation. Both potassium and magnesium are critical electrolytes which impact healthy heart rhythm. Magnesium deficiencies caused by diabetes can, in turn, cause dysregulation in the body’s potassium levels. According to the National Institutes of Health, poorly controlled diabetes can cause magnesium deficiencies, which lead to hypokalemia (low potassium) levels. Individuals with hyperglycemia resulting from uncontrolled diabetes may benefit from taking magnesium supplements, which then help to correct potassium imbalances.
Low potassium can lead to heart rhythm abnormalities.